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Psychopharmacology and Psychiatry Updates
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Latest episodes
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Schizophrenia: Which of Seven Antipsychotics Wins?
October 9, 2026 · 15 minFaculty: Oliver Freudenreich, M.D. Host: Flavio Guzmán, M.D. Learn more about our memberships here Earn 0.75 CMEs: Quick Take Vol. 85 Schizophrenia: Which of Seven Antipsychotics Wins on Acute Efficacy and Safety?
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SSRI Dosing for OCD: Beyond FDA Guidelines
October 3, 2026 · 9 minFaculty: Robert Hudak, M.D. Host: Flavio Guzmán, M.D. Learn more about our memberships here Earn 1.25 CME: SSRI Dosing for OCD: Beyond FDA Guidelines Treatment-Resistant OCD: From SSRIs to Augmentation
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Trazodone for Insomnia and Comorbid Depression
September 28, 2026 · 11 minIn this episode, we explore a new meta-analysis reconciling trazodone's real-world reputation with cautious sleep medicine guidelines, examining its effects on sleep architecture and depressive symptoms in patients with comorbid insomnia…
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Antipsychotics, Prolactin, and Sexual Side Effects
September 23, 2026 · 9 minIn this episode, we explore why antipsychotics cause hyperprolactinemia and sexual side effects, a leading reason patients quietly stop treatment. Dr. Oliver Freudenreich breaks down which medications carry the highest risk, the long-term…
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EMERGENT-5: Cobenfy and Treatment Durability
September 18, 2026 · 13 minIn this episode, we sit down with Dr. Oliver Freudenreich to unpack EMERGENT-5, the year-long trial tracking Cobenfy's real-world durability and safety in schizophrenia. We explore whether early symptom gains hold up over time, what side…
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Antipsychotics and Weight Gain
September 13, 2026 · 15 minIn this episode, we sit down with Dr. Oliver Freudenreich to unpack antipsychotic-induced weight gain — why it happens, which medications carry the highest risk, and how to build a proactive ABC strategy using switching, metformin, and…
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EPA vs. DHA: Fish Oil and Treatment-Resistant Depression
September 8, 2026 · 13 minIn this episode, we explore whether EPA, a specific omega-3 fatty acid, can help patients with treatment-resistant depression. Dr. Derick Vergne breaks down the clinical evidence, dosing, and the anti-inflammatory mechanisms that may…
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AUD Medications and Hepatic Safety
September 3, 2026 · 10 minIn this episode, we explore how liver status shapes medication choice for alcohol use disorder. Dr. Kevin Sevarino breaks down a practical algorithm for selecting between naltrexone, acamprosate, disulfiram, and other options, tailored to…
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GLP-1 Agonists in Serious Mental Illness: Current Evidence
August 29, 2026 · 15 minIn this episode, we explore whether GLP-1 agonists like semaglutide can tackle the metabolic toll of antipsychotics in schizophrenia. Can a drug famous for celebrity weight loss actually protect our most vulnerable psychiatric patients…
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Gabapentin, Topiramate & Baclofen in AUD
August 24, 2026 · 17 minIn this episode, we explore three off-label but evidence-supported medications — gabapentin, topiramate, and baclofen — for alcohol use disorder, examining their mechanisms, dosing strategies, tolerability challenges, and which patients…
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Deprescribing Benzodiazepines: When Tapering Might Do More Harm Than Good
August 19, 2026 · 17 minIn this episode, we explore the nuanced landscape of benzodiazepine tapering, guided by a major 2024 joint clinical practice guideline. Are we training a generation of psychiatrists too afraid to prescribe one of psychiatry's most…
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Disulfiram Unpacked: Efficacy, Risks, and Liver Safety
August 14, 2026 · 16 minIn this episode, we explore disulfiram (Antabuse), one of the oldest FDA-approved treatments for alcohol use disorder. Dr. Kevin Sevarino breaks down its mechanism, efficacy data, and critical hepatic safety considerations. Could enforced…
About the show
Practical psychopharmacology updates for mental health clinicians. Useful for psychiatry / mental health professionals. Expert interviews and soundbites from CME presentations. Practical and free of commercial bias. Not sponsored by any pharmaceutical company.