Mind & Matter
Today: #70 in Science, New Zealand on our combined chart.
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Latest episodes
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This Animal Survives 18 Minutes Without Oxygen | Gary Lewin | Ep 309
October 12, 2026 · 1 hr 40 minSend us Fan Mail Nick talks with Prof. Gary Lewin (Max Delbrück Center, Berlin) about naked mole-rats, which in lab tests survived 18 minutes in pure nitrogen by shutting down brain activity, keeping the heart beating, and switching to…
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Low Selenium Doubles Your Heart Attack Risk | Lutz Schomburg | Ep 308
October 5, 2026 · 1 hr 44 minSend us Fan Mail Nick talks with Prof. Lutz Schomburg about selenium biology in the endocrine system: selenoprotein P as the liver’s selenium transport protein and status biomarker, autoantibodies that can impair delivery despite normal…
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What we're getting WRONG about cane sugar & corn syrup | Kimber Stanhope | Ep 307
September 15, 2026 · 1 hr 52 minSend us Fan Mail Controlled human feeding trials show added fructose raises liver fat, triglycerides, uric acid, and insulin resistance at real-world doses. TOPICS DISCUSSED: Glucose vs Fructose in the Liver: Glucose and fructose are…
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Why Bigger Brains Get More Mutations | Christopher Walsh | Ep 306
August 28, 2026 · 1 hr 45 minSend us Fan Mail How genomics is used to study what makes a human brain, and how genetically damaged neurons get removed. TOPICS DISCUSSED: Scale & Size: A human brain is about three times a chimpanzee brain by mass, but the larger change…
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Why THC Users Eat More but Don't Gain Weight | Nephi Stella | Ep 305
August 20, 2026 · 1 hr 41 minSend us Fan Mail The biology of endogenous cannabinoids & history of cannabinoid-based therapeutics TOPICS DISCUSSED: Anandamide vs 2-AG: The two major endocannabinoids with a shared arachidonic acid backbone but distinct head groups…
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The Gene Variant Linked to Living to 100 | Pinchas Cohen | Ep 304
August 12, 2026 · 1 hr 47 minSend us Fan Mail Mitochondrial peptides act as stress signals that regulate metabolism, muscle mass, and neurodegeneration. TOPICS DISCUSSED: Mitochondria as Communication Hubs: Beyond ATP production, mitochondria encode peptides that…
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Pain, Inflammation, Peptides & Healing | Isaac Chiu | Ep 303
August 5, 2026 · 1 hr 45 minSend us Fan Mail How the nervous and immune systems communicate, using peptides and other signals, to regulate pain, itch, and inflammation. TOPICS DISCUSSED: Nociception & Pathogens: Sensory neurons detect bacterial toxins within seconds…
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Mitochondrial Peptide That Doubled Running | David Lee | Ep 302
July 30, 2026 · 1 hr 50 minSend us Fan Mail Mitochondrial peptide MOTS-c is a stress-induced signal that reprograms cell metabolism. TOPICS DISCUSSED: Mitochondrial Roles: Not just ATP production, but “speaker of the house” via communication molecules that “talk” to…
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What we're getting WRONG about copper peptides | Rahi Sarbaziha | Ep 301
July 22, 2026 · 50 minSend us Fan Mail GHK-Copper and peptides in skin care, aging, and general health. TOPICS DISCUSSED: Endogenous Decline: GHK-copper levels peak in young adulthood then fall with age, reducing natural support for skin repair and collagen…
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What we're getting WRONG about the "leaky" aging brain | William Banks | Ep 300
July 15, 2026 · 1 hr 45 minSend us Fan Mail Blood-brain barrier as a dynamic interface allowing selective passage of nutrients, peptides, and gut hormones. TOPICS DISCUSSED: Blood-Brain Barrier Structure: Capillary endothelial cells with tight junctions, absent…
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Too Much Iron and the Aging Brain | Dr. Pamela Maher | Ep 299
July 8, 2026 · 1 hr 43 minSend us Fan Mail Ferroptosis, an iron-dependent cell death pathway driven by lipid peroxidation; chronoferoptosis, in which chronic stress sensitizes neurons gradually. TOPICS DISCUSSED: Cell Death Pathways: Apoptosis proceeds through…
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Ozempic Reaches Your Brain in Ways Your Own GLP-1 Can't | Katrin Svensson | Ep 298
June 30, 2026 · 1 hr 35 minSend us Fan Mail Endogenous peptide diversity, GLP-1 drugs, and methods for novel peptide discovery. TOPICS DISCUSSED: Peptide Structure & Production: Short amino acid chains (3-50 residues) cleaved from larger precursors by PCSK enzymes…

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