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Science

This Week in Neuroscience

by Vincent Racaniello
Life SciencesScienceNatural Sciences

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Latest episodes

  • Arc, tau, and Alzheimer's

    September 29, 2026 · 1 hr 9 min

    Jason Shepherd joins TWiN to discuss the work in his laboratory showing that Arc protein plays a role in intercellular transmission of tau protein, which becomes hyperphosphorylated and misfolded, a major histopathological hallmark of…

  • Plastic astrocyte networks with Melissa Cooper

    July 30, 2026 · 1 hr 6 min

    Melissa Cooper joins TWiN to discuss her discovery that astrocytes connect specific brain regions through plastic networks. Hosts: Vincent Racaniello and Tim Cheung Guest: Melissa Cooper Subscribe (free): Apple Podcasts, Google…

  • The price of a bigger brain

    June 25, 2026 · 1 hr 27 min

    TWiN unpacks a striking paradox, that the very cell divisions that built the human brain's most advanced layers also put them at greatest risk, and how a dedicated DNA repair pathway saves them. Hosts: Vincent Racaniello, Vivianne…

  • TWiN 72: What cesarean babies miss

    June 1, 2026 · 1 hr 9 min

    TWiN explains the finding that vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via synthesis of a sphingosine derivative on neonatal skin. .Hosts: Vincent Racaniello, Vivianne Morrison, and…

  • Psychedelics rewire the brain from within

    April 29, 2026 · 1 hr 31 min

    TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds. Hosts: Vincent Racaniello…

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  • Unraveling the axon wrap

    March 17, 2026 · 1 hr 19 min

    TWiN explains the role of a ubiquitin ligase component in regulating the sheathing of multiple axons by Schwann cells. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS…

  • Fibromyalgia and the microbiome

    March 5, 2026 · 1 hr 11 min

    TWiN explains a study which showed that transplanting gut microbiota from women with fibromyalgia into mice induces pain, as well as phenotypes commonly observed in patients, such as immune activation, metabolomic changes, and reduced skin…

  • Firewall for the brain

    January 27, 2026 · 1 hr 14 min

    TWiN explores the use of speech brain-computer interfaces to restore communication to people with paralysis, and reveals strategies for protecting private inner speech. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung…

  • Interpreting situation-specific facial signals

    December 24, 2025 · 1 hr 31 min

    TWiN explores how theta phase shifts mediate contextual perception of facial expressions during everyday social interactions. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google…

  • Neuroscience of overeating

    November 26, 2025 · 1 hr 24 min

    TWiN reviews the underlying neurobiological mechanisms of overeating and obesity, the role of the hypothalamus and reward systems in controlling food intake and energy balance, and how dysregulation in these systems leads to overeating…

  • Air pollutants promote dementia

    November 4, 2025 · 1 hr 37 min

    TWiN explains epidemiological data showing that exposure to air pollution was associated with an increased risk of developing Lewy body dementia, and nasal administration of air pollution in mice led to brain atrophy and impaired cognition…

  • How the brain decides what we see

    October 8, 2025 · 1 hr 14 min

    TWiN explains how visual neurons show functional flexibility by selectively responding to subsets of inputs representing attended objects while ignoring those conveying information about irrelevant objects. Hosts: Vincent Racaniello…

Full episode archive on Apple Podcasts →

About the show

A podcast about the nervous system.