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Latest episodes
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SE5:E5 - Part 2: Protecting Groups? We Need to Talk: Manufacturing MK-0616 with Enzyme Cascades
October 19, 2026 · 31 minPart 1 laid out the strategy. Now, it’s time to make the molecule. Four enzymes, one vessel, and plenty of competing amines. What could possibly go wrong? Dani and LC return with Stephanie Galanie, Director in Biocatalysis, and Artis…
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SE5:E4 - Part 1: Protecting Groups? We Need to Talk: Manufacturing MK-0616 with Enzyme Cascades
October 19, 2026 · 30 minHow do you design a manufacturing process for a molecule as complex as MK-0616? In Part 1 of this Pharm to Table series, Dani and LC join Stephanie Galanie, Director in Biocatalysis, and Artis Klapars, Distinguished Scientist in Process…
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SE5:E3: A Process Chemist's Romance with Scaling a Macrocyclic Peptide
August 11, 2026 · 35 minLast episode, we watched medicinal chemistry dream up enclitide (MK-0616) — this week we find out what happens when someone actually has to make it. Dani and LC are joined by David Thaisrivongs and Gao Shang to unpack their…
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SE5:E2: The Macrocyclic Mullet
July 15, 2026 · 27 minWhat happens when the textbook SAR playbook stops working? On this episode of Pharm to Table, Rob Garbaccio joins Dani and LC to share the discovery story behind enlicitide (MK-0616), a journey filled with unusual SAR, creative…
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SE5:E1 - A Journey of Synthetic Chemistry Innovations at Merck
May 18, 2026 · 41 minTo kick off Season 5, Dani and LC discuss a recent perspective published in the Journal of Organic Chemistry that highlights innovations in synthetic chemistry which trace their origins to the work of discovering, developing and…
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SE4:E8: From Discovery to Process, Part 2: Getting Ugi with it - scaling a 3CL protease inhibitor
March 23, 2026 · 31 minIn Part 2 of our Pharm to Table deep dive on MK‑7845, Dani and LC shift from invention to implementation, welcoming process chemists Nastaran Salehi Marzijarani and Ben Turnbull to the pod. We explore how the team re‑imagined the synthesis…
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SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
February 2, 2026 · 29 minIn this first installment of our two‑part Pharm to Table special on MK‑7845, Dani and LC sit down with medicinal chemist Valerie Shurtleff to unpack the discovery journey behind this 3CL protease inhibitor—from early structural insights to…
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SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
November 10, 2025 · 31 minJoin us for a conversation with Yining Ji Chen, recipient of the 2025 ACS Rising Star Award, on how mechanistic insight powers innovation in pharmaceutical process research. We dive into her career journey and standout projects—from…
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SE4:E5 - Evolution of a Green Chemistry Trailblazer
October 13, 2025 · 37 minIn this episode, Dani and LC welcome Jeff Moore, recipient of the 2025 ACS Affordable Green Chemistry Award, to discuss his pioneering work in biocatalysis at Merck. The conversation explores the evolution (pun intended) of biocatalytic…
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SE4:E4 - MedChem Masters: Molecules, Mentors and Mindsets
August 19, 2025 · 36 minIn this episode, Dani and LC interview Dr. Shane Krska, recipient of the ACS Arthur C. Cope Award, and Dr. Petr Vachal, recipient of the ACS Earle B. Barnes Award for Leadership in Chemical Research Management. Shane shares his pioneering…
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S4:E3 - London Calling ... Spirocycles
May 19, 2025 · 34 minThis month we sit down with Damien Valette, Olivia Boyd and David Petrone to chat about their latest paper in Organic Letters on the desymmetrization of prochiral dienones to control all-carbon quaternary centers. This reaction leverages…
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S4:E2 - Making Sulfur Smell like Success!
April 21, 2025 · 27 minJoin us on the Pharm to Table podcast for a delightful chat with Ethan Wappes from our South San Francisco site, as we dive into the exciting world of thiophene synthesis! Ethan is a member of our Discovery Process Chemistry group and…
About the show
A podcast hosted by L.-C. Campeau and Dani Schultz that dives into the stories about the people behind the chemistry and science that happens at #MerckChemistry.
Follow us on X (formerly Twitter) at @PharmToTablePod, @DrLCSquare, @danithechemist
Email us comments and suggestions at pharmtotablepod@gmail.com