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Paper Talk
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About the show
Sharing research articles, tracking the latest developments
Latest episodes
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1663-Single-Cell Atlas Across Brain Disorders
October 10, 2026 · 23 minThe paper describes the PsychAD cohort, a massive single-nucleus transcriptomic study of the human dorsolateral prefrontal cortex involving over 6.3 million nuclei from 1,494 donors. This research creates a comprehensive cellular atlas to…
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1662-Tri-Modal Antiplatelet Nanomotors for Arterial Thrombus
October 10, 2026 · 25 minThis research article describes the development of a carrier-free antiplatelet nanomotor designed for the advanced treatment of acute arterial thrombosis. The authors engineered a specialized nanosystem by co-assembling a photothermal…
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1661-Virtual Cell Challenge 2026
October 10, 2026 · 26 minThe 2026 Virtual Cell Challenge introduces a rigorous benchmark designed to evaluate how well computational models can predict gene knockdown responses in entirely new biological environments. Building on the findings of the inaugural 2025…
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1660-Multimodal Mapping of Tissue Genome Architecture
October 9, 2026 · 26 minThe paper introduce Spatial Hi-C-RNA, a pioneering multimodal technology that simultaneously maps three-dimensional genome architecture and whole-transcriptome profiles within intact tissue sections. By integrating microfluidic barcoding…
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1659-Genome-Scale Perturb-Seq Mapping of Human T Cell
October 9, 2026 · 25 minResearchers developed a massive genome-scale perturb-seq platform to map the regulatory networks of 22 million primary human CD4+ T cells. By systematically knocking down over 12,000 genes across different activation states, they created a…
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1658-Cellular Self-Reporting for Live-Cell Transcriptomics
October 9, 2026 · 25 minThe paper introduces cellular self-reporting, a novel bioengineering platform that uses engineered virus-like particles (VLPs) to monitor gene expression in living cells without destroying them. By repurposing the MMLV Gag protein…
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1657-Cross-Species Single-Cell Atlas of the Striatum
October 8, 2026 · 28 minThis comprehensive single-cell atlas of the human and mouse striatum provides a detailed map of neuronal diversity and subregional specialization. By profiling over 400,000 nuclei, researchers identified rare neuronal subtypes, such as…
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1656-Tabula Sapiens 2.0: A Atlas of Human Cells
October 8, 2026 · 27 minThe research introduces Tabula Sapiens 2.0, an expansive transcriptomic atlas that profiles over 1.1 million individual human cells across 28 different tissues from 24 donors. By utilizing standardized single-cell processing, the Tabula…