JAMA Clinical Reviews

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Latest episodes

• Narcolepsy: A Review

  October 5, 2026 · 21 min

  Narcolepsy is a chronic neurologic disorder that causes severe daytime sleepiness and impaired quality of life. Author Tom Scammell, MD, of Harvard Medical School joins JAMA Deputy Editor Karen Lasser, MD, MPH, to discuss the etiology…

• Influenza, RSV, and COVID-19 Vaccines: Effectiveness, Safety, and Trust in 2026

  September 30, 2026 · 14 min

  Respiratory virus vaccine effectiveness and safety for influenza, RSV, and COVID-19 are reviewed, including new evidence, risks, and recommendations. JAMA Deputy Editor Preeti Malani, MD, MSJ, speaks with Rochelle Walensky, MD, MPH…

• Vaccines for Cancer Treatment

  September 21, 2026 · 20 min

  Cancer vaccines stimulate immune cells to recognize proteins or mutations found on or within cancer cells, facilitating destruction of cancer cells. Several vaccines are approved and others are in development for cancer treatment. Author…

• Idiopathic Normal Pressure Hydrocephalus: Diagnosis and Treatment

  September 14, 2026 · 19 min

  Idiopathic normal pressure hydrocephalus (iNPH) affects approximately 1% to 4% of adults aged 65 years and older and is associated with gait impairment, cognitive decline, and urinary dysfunction. Author Mark G. Luciano, MD, PhD, from…

• Rheumatoid Arthritis

  September 10, 2026 · 23 min

  Rheumatoid arthritis can affect any synovial joint and cause irreversible damage, but early diagnosis and treatment with DMARDs can reduce inflammation and lower the risk of joint destruction. JAMA Associate Editor David Simel, MD, MHS, is…

• An Overview of Postural Orthostatic Tachycardia Syndrome (POTS)

  August 24, 2026 · 29 min

  POTS is a chronic autonomic disorder characterized by excessive orthostatic tachycardia and multisystem symptoms that affects an estimated 0.1% to 1% of the US population. Author Satish Raj, MD, MSCI, of University of Calgary Cumming…

• Medication Treatments for Alcohol Use Disorder

  August 19, 2026 · 20 min

  Naltrexone, acamprosate, disulfiram, and topiramate are effective but underused medications for treatment of alcohol use disorder. Author Stephen Holt, MD, MS, of Yale School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to…

• Liquid Biopsy Tests for Cancer

  August 10, 2026 · 24 min

  Circulating tumor DNA (ctDNA)(liquid biopsies) can help monitor cancer progression, detect residual cancer after treatment, and identify genetic changes within cancer cells that could affect treatment response. Author Ben Ho Park, MD, PhD…