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JACC Author Interviews
From American College of Cardiology
Health & Fitness
JACC Deep Dive
by American College of Cardiology
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Latest episodes
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The STEP Trial and the Importance of Early Intensive Blood Pressure Control | JACC Deep Dive
October 20, 2025 · 11 minDr. Harlan Krumholz reviews the STEP trial, which studied over 8,500 older adults in China to compare intensive versus standard blood pressure control. The trial found that lowering systolic blood pressure to 110–130 mm Hg significantly…
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Percutaneous Mechanical Aspiration: A New Frontier in Endocarditis Care | JACC Deep Dive
September 15, 2025 · 7 minIn this episode of JACC Deep Dive, Editor-in-Chief Dr. Harlan Krumholz explores groundbreaking findings from the CLEAR-IE registry—the largest study to date on percutaneous mechanical aspiration (PMA) for right-sided infective…
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Understanding Angina Symptom Trajectories After Invasive vs. Conservative Treatment | JACC Deep Dive
September 8, 2025 · 8 minIn this JACC Deep Dive, Dr. Harlan Krumholz highlights a study by Ikemura et al. that used data from the ISCHEMIA trial to model how angina symptoms evolve over three years in patients with stable coronary disease treated either invasively…
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Tirzepatide in HFpEF and Obesity: Consistent Benefits Regardless of Diabetes Status | JACC Deep Dive
September 3, 2025 · 12 minIn this JACC Deep Dive, Dr. Harlan Krumholz discusses a pre-specified analysis from the SUMMIT trial, which evaluated the effects of tirzepatide in patients with heart failure with preserved ejection fraction (HFpEF) and obesity, both with…
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Environmental Exposure as Intervention: HEPA Filtration and Blood Pressure Near Traffic Corridors | JACC Deep Dive
August 18, 2025 · 8 minIn this Deep Dive, Editor-in-Chief Dr. Harlan Krumholz explores a pragmatic, randomized crossover trial testing whether in-home HEPA filtration can reduce blood pressure in adults living near high-traffic roadways. The findings offer early…
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Master DAPT | JACC Deep Dive
August 11, 2025 · 7 minIn this episode of JACC Deep Dive, Dr. Harlan Krumholz explores new insights from a post hoc analysis of the MASTER DAPT trial, highlighting the real-world burden of ischemic and bleeding events in high bleeding risk patients after PCI. By…
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Cardiac Biomarkers in ATTR-CM From HELIOS-B | JACC Deep Dive
August 4, 2025 · 7 minIn this episode of JACC Deep Dive, KACC Editor-in-Chief Harlan M. Krumholz, MD, SM, FACC, explores a post hoc analysis of the HELIOS-B trial, which examined whether echocardiographic parameters can track treatment response in…
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Insights From the INTERASPIRE Study | JACC Deep Dive
July 31, 2025 · 11 minJACC focuses in again on Lipids in our June 3 issue, bringing critical insights into emerging targeted therapies. In the June 3 Deep Dive, editor-in-chief Harlan M. Krumholz, MD, SM, FACC, reviews the INTERASPIRE study by Ray et al…
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Vutrisiran Impact on Functional Capacity and QOL | JACC Deep Dive | JACC
July 31, 2025 · 8 minGo behind the scenes with JACC as editor-in-chief Harlan M. Krumholz, MD, SM, FACC, talks about what 's caught his attention in the latest JACC issue on amyloid. In this paper by Sheikh et al, the authors did a pre-specified exploratory…
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Individual Variation in Tirzepatide Response | JACC Deep Dive
July 31, 2025 · 8 minJoin JACC Editor in Chief Harlan Krumholz, MD, SM, as he speaks about this ACC.25 presentation published in JACC. This fascinating study by Rohan Khera et al independently analyzed patient-level data from the SURMOUNT trials of tirzepatide…
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Revisiting the SUMMIT Trial | JACC Deep Dive
July 31, 2025 · 6 minThis JACC Deep Dive in our May 13 issue highlights new findings from the SUMMIT CKD study, showing that terzepatide improves symptoms, function, and weight in patients with HFpEF and obesity—regardless of kidney function. The analysis also…
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1-Year Results of ADVANTAGE AF | JACC Deep Dive
July 31, 2025 · 7 minIn this JACC Deep Dive episode, Dr. Harlan Krumholz reviews the ADVANTAGE-AF trial, which evaluated pulse field ablation (PFA) as a treatment for persistent atrial fibrillation. The study demonstrated that PFA is a safe and effective…
About the show
JACC Deep Dive explores the methodology, interpretation, and impact of key studies published in JACC.