Health & Fitness

CRITKNOW

by Bharath Kumar Tirupakuzhi Vijayaraghavan

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Critical Care Reviews Podcast

Latest episodes

Bicarbonate for in-hospital cardiac arrest

October 15, 2026 · 22 min

In this 10th episode of our podcast, we discuss the recently published BIHCA trial that evaluated sodium bicarbonate for in-hospital cardiac arrest. As always, we discuss the rationale, PICO, results, limitations and provide our…
Beyond the Data: Middle Meningeal Artery Embolization

September 9, 2026 · 30 min

In this BTD episode, we are joined by senior neurosurgeon and neuro-endovascular intervention specialist Dr. Srinivasan Paramasivam. We unpack the rationale, indications, and evolution of evidence behind middle meningeal artery…
Middle Meningeal Artery Embolization for Chronic SDH: STEM trial

September 1, 2026 · 31 min

In this episode, we review the evidence on middle meningeal artery embolization for chronic subdural hematoma, with a deep dive into the STEM trial and a brief overview of other key studies. Alongside a critical appraisal of the clinical…
LOGICAL

August 8, 2026 · 38 min

In this episode, we review the LOGICAL trial, which compared conservative versus liberal oxygenation targets in patients admitted to the ICU following cardiac arrest. We discuss the underlying rationale, summarize prior evidence, and…
SODa-BIC

July 9, 2026 · 41 min

In this episode, we break down the recently published SODa-BIC trial, exploring the role of IV sodium bicarbonate in critically ill patients with metabolic acidemia. We walk through the rationale, prior evidence, PICO, results, and our key…

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ARISE Fluids

June 23, 2026 · 34 min

In this episode, we review the recently published ARISE-Fluids trial, which compared a restrictive fluid strategy with early vasopressor use against a more liberal fluid approach with delayed vasopressors. We place the trial in context…
Beyond the Data: FAST

June 2, 2026 · 27 min

In this 2nd episode of BTD, we speak with Dr. Nandini Sethuraman, Chief of Microbiology at the Apollo Central Reference Laboratory in Chennai. We discuss microbiology lab workflows, the different methods involved in species identification…
The FAST trial: Rapid vs. Standard AST

June 2, 2026 · 36 min

In this episode, we discuss the FAST trial that compared a new and rapid antibiotic susceptibility test to standard practice. We discuss the rationale, trial design, the DOOR outcome framework and its analytical approach, and the…
TIGRIS trial

May 8, 2026 · 46 min

In this episode, we discuss the recently published Tigris trial, which evaluated the role of Polymyxin B hemoadsorption in patients with septic shock. We explore the trial’s rationale, trace the evolution of evidence in this area, examine…
Beyond the Data: SOHO

April 17, 2026 · 17 min

We’re excited to introduce Beyond the Data (BTD), a new CRITKNOW series where we invite expert clinicians and researchers to share their insights and interpret results beyond the numbers. In this first episode, we’re honoured to host…
SOHO trial: HFNC vs. Standard Oxgen Therapy

April 17, 2026 · 27 min

In this third episode of our podcast, we discuss the recently published SOHO trial. We explore the physiological benefits of HFNC, review the existing evidence, and critically appraise the trial. We also include a brief methods segment on…
Ketamine vs. Etomidate: the RSI trial

March 30, 2026 · 28 min

Welcome to the 2nd episode of CRITKNOW! In this episode we are focusing on the RSI trial that compared Ketamine vs. Etomidate for intubating critically ill patients. CRITKNOW will focus on a variety of themes related to the practice of…

Full episode archive on Apple Podcasts →

About the show

Our take on the latest critical care evidence with deep insights on methods, interpretation, clinical relevance and so much more! CRITKNOW is co-hosted by Bharath Kumar Tirupakuzhi Vijayaraghavan and Ramesh Venkataraman. Bharath is a mid-career clinician–researcher with a primary focus on improving outcomes from critical illness in patients in low- and middle-income countries (LMICs). He is also deeply passionate about teaching evidence-based medicine and helping clinicians interpret and apply emerging evidence in patient care. You can learn more about his work here: https://www.researchgate.net/profile/Bharath-Kumar-Tirupakuzhi-Vijayaraghavan?ev=hdr_xprf Ramesh is American Board–certified in Internal Medicine, Critical Care Medicine, and Neurocritical Care. He is also a senior researcher with a special interest in acute kidney injury and renal replacement therapy. A highly respected teacher and educator, he has a unique ability to integrate emerging evidence into bedside clinical practice. You can learn more about his work here: https://icuconsultants.com/dr-ramesh-venkataraman/ Bharath and Ramesh are both Senior Consultants in the Department of Critical Care Medicine at Apollo Hospitals, Chennai and affiliated with Chennai Critical Care Consultants Private Limited, an academic critical care group practice (https://icuconsultants.com/). Bharath is also affiliated with the University of Edinburgh as a Clinical Research Fellow (https://inflammation-research.ed.ac.uk/research/research-groups/dr-bharath-kumar) Views expressed are personal.