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The Life Sci Fantastic
Similar topics: medicines and breakthroughs
Health & Fitness
Behind the Breakthroughs
by Inside Precision Medicine
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Ranking history · United States
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Latest episodes
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Hussam Al Kateb: Inside Mayo Clinic’s Genomic Diagnostics Revolution
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Matt Begemann: The Cancer-Killing CRISPR
October 7, 2026 · 46 minWhat began as a search for plant-friendly CRISPR tools led Matt Begemann, PhD, and colleagues to Cas12a2, or CasCLEAR, an unusual system that can trigger broad nucleic acid damage after recognizing an RNA target, creating potential…
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Wei-Wu He: Craig Venter’s Legacy and the Future of Human Longevity
September 23, 2026 · 1 hr 2 minHuman Longevity executive chairman Wei-Wu He discusses how the integration of genomics, advanced imaging, and artificial intelligence could transform disease prediction and personalized preventive medicine. Reflecting on Craig Venter’s…
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Palani Kumaresan: Roche Diagnostics Is Ramping Up—Should Illumina Be Worried?
September 9, 2026 · 59 minRoche’s AXELIOS sequencer, Alzheimer’s blood test, and push to automate mass spectrometry point to a broader strategy of making advanced diagnostics routine. Whether AXELIOS can meaningfully challenge Illumina’s sequencing dominance…
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Ken Greenberg: Can Ultrasound Shatter the Gene Therapy Delivery Bottleneck?
August 26, 2026 · 52 minGene therapy’s biggest bottleneck remains delivery: getting increasingly sophisticated genetic medicines safely into the right cells. SonoThera is taking a radically different approach, using ultrasound and microbubbles instead of viral…
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David Thaisrivongs: Goldilocks and the First Oral PCSK9 Inhibitor
August 12, 2026 · 42 minBiocatalysis has evolved from a scientific curiosity into a powerful manufacturing platform, culminating in enlicitide, the first oral macrocyclic peptide PCSK9 inhibitor. Merck’s David Thaisrivongs explains how enzyme engineering helped…
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Beaubrun and Acharya: No Antibiotic Without a Diagnostic
July 29, 2026 · 57 minAntimicrobial resistance (AMR) isn't going to be solved by new antibiotics alone—it also requires identifying resistant infections quickly enough to guide treatment and prevent transmission. In this episode of Behind the Breakthroughs…
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Amit Etkin: Precision Psychiatry’s Future Isn’t Genomics—It’s Brain Activity
July 15, 2026 · 1 hr 1 minFor decades, psychiatry has relied on symptom-based diagnosis and trial-and-error treatment, but precision medicine is set to transform mental health care by using objective biological measures—such as EEG, sleep and circadian rhythm data…
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Michael Antonov: From Virtual World Builder to Real-World Drug Designer
July 1, 2026 · 1 hr 2 minAI is transforming biomedical research, but meaningful advances in drug discovery require more than just increasingly powerful algorithms—they depend on combining machine learning with physics-based simulations, mechanistic models, and…
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Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders
June 17, 2026 · 59 minPhilippe Pouletty, MD, is one of Europe’s most successful life sciences entrepreneurs, having spent more than 30 years building category-leading biotechnology and medical technology companies from breakthrough scientific innovations. His…
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Arthur Caplan: The Right to Life, Liberty, and Pursuit of Health
June 3, 2026 · 1 hr 1 minWhile growing up during the polio era, Arthur Caplan, PhD, saw doctors hide painful truths from families and children, which sparked his lifelong questions about power, protection, and inequality in medicine. In this episode, Caplan claims…
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Carolina Aguilar: Brain-Computer Interfaces that Heal Neural Circuits
May 20, 2026 · 55 minBrain-computer interfaces have gained widespread attention largely for assistive applications, but Carolina Aguilar sees their greatest potential in directly treating neurological disease. Through INBRAIN Neuroelectronics, she is…
About the show
Medicine is full of breakthroughs. Most don't become medicine. Behind the Breakthroughs explores scientific ideas that could change how we diagnose and treat disease—and what it will take for them to work. Host Jonathan D. Grinstein, PhD, a scientist-turned-journalist, speaks with the researchers, physicians, and entrepreneurs building the next generation of genetic medicines, diagnostics, AI, precision therapeutics, and biotechnology. Hosted on Acast. See acast.com/privacy for more information.