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Science

Approved

by Alex Kesin and Matthew Pech
Life SciencesScienceBusiness

Last recorded placements from this show’s chart history. These are not current rankings.

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Ranking history · United States

Latest daily rankings: Oct 27. New rankings will appear after the next update.

Recent history only — this show has no current ranking on the Science chart. These are recorded positions from the last 14 days, not current rankings.

Position on the Science combined chart over the last 14 days. Toggle platforms to compare their positions. Lower rank numbers are better.

#113#135#158#180#202Chart rankOct 15Oct 18Oct 21Oct 24Oct 27
View as table
DateCombined RankApple Podcasts
Oct 27——
Oct 21—#192
Oct 20#192#178
Oct 19#178#162
Oct 18#174#158
Oct 17#159#141
Oct 16#123#104
Oct 15#189#173
Oct 14#165#149

Latest episodes

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    The wild story of how a Cold War bioweapon became Botox — and how Allergan turned a sleepy ophthalmology drug into an enduring aesthetic franchise. Every part of this story looks nothing like your normal blockbuster drug. Botox started its…

  • What is Approved?

    September 14, 2026 · 3 min

    Approved tells the definitive stories behind the world's most interesting biotech ventures.  Most people learn about the industry in a fragmented, ad hoc way-- an industry article here, a clinical trial readout there, some science…

  • Blueprint Medicines: Chasing Gleevec to a $9B Allergy Drug

    August 4, 2026 · 2 hr 30 min

    Blueprint Medicines was built to find the next Gleevec-style cancer drug. It ended up pivoting to allergic disease instead, and selling to Sanofi for $9B. This is the platform, the pivot, and who got paid. Blueprint Medicines set out to be…

  • Keytruda: How Merck's Pembrolizumab Became the Best-Selling Cancer Drug of All Time

    May 14, 2026 · 2 hr 8 min

    Keytruda is Merck's $31 billion a year PD-1 inhibitor and the best-selling cancer drug of all time. In Episode 3 of Approved, Alex Kesin and Matthew Pech trace the development of pembrolizumab , featuring interviews the scientists who…

  • Episode #2: Geron

    March 13, 2026 · 2 hr 22 min

    Listen on Spotify Listen on Apple Podcasts Listen on YouTube TABLE OF CONTENTS (00:00:00) - Introduction  (00:01:19) - Hayflick Limit  (00:08:30) - Michael West & Founding of Geron  (00:15:16) - Early Science & IP Strategy  (00:27:25)…

Show 1 more episodeShow fewer episodes
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    January 30, 2026 · 1 hr 46 min

    Listen on Spotify Listen on Apple Podcasts Listen on YouTube TABLE OF CONTENTS (00:00:00) - Introduction (00:04:40) - $50 of Dried Lizard Venom (00:29:17) - Fax of Death (00:43:04) - Sleeping Beauty Awakens (00:52:07) - Carl Icahn Sends a…

Full episode archive on Apple Podcasts →

About the show

Life sciences, under the hood. Deep dives into the patent filings, regulatory gauntlets, and capital-risks that shape the business of biology.