Education

Trying To Be Positive With Anne Matthews

by Anne Matthews, RTF Productions

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Latest episodes

A Fertility Story - Multiple Losses, Failed Transfers & Natural Conception at 44

September 22, 2026 · 43 min

Anne is back with Hayley, sharing her fertility journey from egg freezing at 34 through pregnancy at 44. She froze her eggs at 34, did a second retrieval at 38 that included making two embryos with a sperm donor before she'd even met her…
A Fertility Story - Six Pregnancy Losses, IVF & DNA Fragmentation

September 8, 2026 · 60 min

Anne is back with Leslie Fair, sharing three and a half years of trying to build a family that included six pregnancy losses, the pressure of being told her age was the problem despite bloodwork that looked completely normal, and two…
Sperm DNA Fragmentation & Male Fertility: New Research on Egg Repair, Varicoceles & Paternal Age

August 25, 2026 · 49 min

Anne is back solo, breaking down the latest research on sperm biology and why the old "sperm just delivers DNA" model is outdated. She covers a 2025 study from the Wellcome Sanger Institute and Harvard Medical School on "selfish sperm…
PCOS Is Now PMOS: What the Rename Means for Your Fertility, IVF & Metabolic Health

May 26, 2026 · 43 min

Anne is back with a solo episode on one of the biggest shifts happening in women's health right now: the rename from PCOS (polycystic ovarian syndrome) to PMOS (polyendocrine metabolic ovarian syndrome). She breaks down why the old name…
Male Factor Infertility: Varicocele, DNA Fragmentation & Recurrent Loss - A Fertility Story

May 5, 2026 · 54 min

Anne is back with Nico, her first male guest sharing a male factor story. Nico walks through DNA fragmentation climbing from 15% to 24% despite lifestyle changes, discovering he'd had an undiagnosed varicocele for 20 years, being dismissed…

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A Fertility Story - PCOS, Failed IUIs & Endometriosis: LAD Testing at 7%, LIT Therapy & Getting Pregnant Naturally

April 14, 2026 · 32 min

Anne is back with Sarah, who spent three and a half years navigating PCOS, two miscarriages, failed IUIs, and a fertility system that kept offering IVF without explaining why. Sarah shares how she got pregnant spontaneously right after her…
A Fertility Story - Recurrent Miscarriage & Immune Testing: Five Losses, Varicocele Repair & Refusing Unexplained

March 31, 2026 · 56 min

Anne is back with Anna, one of her first patients dealing with immune-related infertility. Anna shares her four-year journey through five miscarriages, multiple failed IVF transfers, and the medical dismissals that made her stop trusting…
Explaining Unexplained Infertility: DNA Fragmentation, Immune Testing & Why Your Lining Matters

March 17, 2026 · 56 min

Anne is back tackling the most frustrating diagnosis in fertility medicine: unexplained infertility. She breaks down why this label almost always means the right questions haven't been asked yet, not that there's actually nothing wrong…
Fertility Clinic Red Flags: Spilling the Tea on Cookie-Cutter Care & What to Ask For

March 3, 2026 · 43 min

Today, Anne tackles the influx of questions from patients feeling let down, gaslit, and stuck in the fertility clinic system. We are diving deep into the diagnostics your clinic should be running—and exactly what to do if they refuse. From…
Fertility Questions I Answer Every Day in Clinic: DNA Fragmentation, Exercise, Coffee & Age

February 10, 2026 · 41 min

Anne is back answering the fertility questions she hears most often from patients—not the ones from Instagram AMAs, but the real concerns that come up after people have already made lifestyle changes. She covers why DNA fragmentation…
Unexplained Infertility, High NK Cells & Saying No to IVF: Fran’s Story

December 9, 2025 · 54 min

When Anne first met Fran, she thought to herself, "She’s a youth... this is going to be a slam dunk." Fran was 26, incredibly healthy, and fit. But after a year of negative tests and chemical pregnancies, she was slapped with the…
AMA: Iron Deficiency & Unexplained Infertility, Luteal Phase Defects vs. Low Progesterone, How Stress Affects Your Cycle & Essential Advice for Patients Over 35

November 25, 2025 · 29 min

In this Ask Me Anything episode, Anne tackles listener questions about some of the most misunderstood aspects of fertility. From why your doctor might not be testing your ferritin levels (even though they should) to the real story behind…

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About the show

Trying to Be Positive is the hand that you've been wanting to hold on your fertility journey. Anne Matthews is a passionate advocate for reproductive health and normalizing the conversation around fertility, labour, loss and menstruation. A busy clinician (with two waitlisted clinics and not enough time to see everyone wanting to be seen), Trying to Be Positive is Anne’s offering to everyone who is trying. Listen for the tools to get closer to your own positive.