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This Week in Microbiology

by Vincent Racaniello
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Latest episodes

  • Bacteria Inside a Fungus Sabotage Plant Defenses

    October 10, 2026 · 51 min

    TWiM explains how bacterial endosymbionts enhance fungal virulence by disrupting the protective rhizobiome, and the development of rationally engineered Salmonella typhimurium strains with enhanced safety and antitumor efficacy.  Become a…

  • DNA Damage as Defense Against Bee Pathogens

    September 26, 2026 · 47 min

    TWiM wonders why archaea are not pathogenic, and reveals how a colibactin produced by a honeybee gut symbiont defends against pathogens. Become a patron of TWiM. Links for this episode: Why are archaea not pathogenic? (mBio)…

  • Why Vegetables Are Good for Your Heart

    September 12, 2026 · 58 min

    TWiM explains the finding that Bunsen burners do not decrease deposition of microbe-containing particles, and how gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits. Hosts:  Vincent Racaniello and Michael…

  • When Gut Bacteria Share Chromosomes

    August 29, 2026 · 52 min

    TWiM explains how movement of DNA among gut bacteria drive large-scale genome mosaicism, and validation of a method for detection of Cyclospora cayetanensis in outbreak-linked fresh produce. Hosts:  Vincent Racaniello, Michael Schmidt…

  • Bacteria and Colon Cancer Recurrence

    August 14, 2026 · 53 min

    TWiM explains the discovery of an avirulent bacterial signature associated with the development of recurrence following colorectal cancer surgery, and phage-derived proteins and conjugates that induce pilus detachment. Hosts:  Vincent…

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  • Nitrogen Fixation Goes Eukaryotic

    July 31, 2026 · 56 min

    TWiM explains major implications of the link between plastic pollution and antimicrobial resistance, and the discovery of a new organelle, the nitrogen-fixing nitroplast. Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson…

  • Kin Killing and Metal Hunger

    July 18, 2026 · 48 min

    TWiM explains how cannibalism shapes biofilm structure and composition in Bacillus subtilis, and the importance of manganese uptake in uropathogenic E. coli during urinary tract infection. Become a patron of TWiM. Links for this…

  • Gut Microbes and ALS

    July 4, 2026 · 58 min

    TWiM explains the connection between inflammation caused by microbial glycogen in the gut and amyotrophic lateral sclerosis, and how disruption of cysteine metabolism leads to synthetic lethality and in vivo fitness impairment in…

  • Remembering Elio at Tufts

    June 15, 2026 · 56 min

    TWiM visits Tufts University School of Medcine and are joined by John Coffin, Michael Malamy, and Verna Manni for a tribute to Elio Schaechter who was chair of Molecular Biology and Microbiology for 23 years. Hosts: Vincent…

  • Nanopore to the bone

    May 28, 2026 · 49 min

    TWiM explains how Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae facilitating transformation, and microbial dominance in diabetic foot osteomyelitis determined with nanopore sequencing. Hosts: Vincent…

  • Bacteria Complete Your tRNA

    May 9, 2026 · 56 min

    TWiM explains how an enhanced domestication method allows for growth of uncultured bacteria, and identification of the oncogene SLC35F2 as is a high-specificity transporter for the micronutrients queuine and queuosine. Hosts: Vincent…

  • How a Gut Microbe Worsens Heart Disease

    April 24, 2026 · 59 min

    TWiM explains a candidate signature of health in the gut microbial community, and how an intestinal bacterium exacerbates cardiac ischemia/reperfusion injury. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson and Petra Levin…

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About the show

This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.