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The Stem Cell Report with Janet Rossant

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Latest episodes

  • Two Decades of iPS Cells: Perspectives from the Field

    October 7, 2026 · 30 min

    In 2006, Kazutoshi Takahashi and Shinya Yamanaka at Kyoto University published their landmark paper showing that mouse skin cells could be reprogrammed to an embryonic-like state using just four transcription factors. Over the past two…

  • Repair the Second Brain

    August 25, 2026 · 56 min

    The enteric nervous system (ENS) is an intricate network of neurons and glia lining the gastrointestinal tract, regulating digestion and overall health. Loss of ENS neurons, as occurs in Hirschsprung disease, leads to intestinal…

  • Born Without a Nose

    June 22, 2026 · 37 min

    Bosma arhinia microphthalmia syndrome (BAMS) is a rare genetic disorder resulting in babies born without a nose, along with eye and reproductive anomalies. Our guests today investigated the developmental basis of this distinct defect using…

  • Therapeutic Strategy for COVID-19-Induced Acute Respiratory Distress Syndrome

    May 20, 2026 · 49 min

    Acute respiratory distress syndrome (ARDS) induced by COVID-19 was a leading cause of severe illness and death during the pandemic, driven by an intense innate immune response, hyperinflammation, and a decrease in lymphocytes. Mesenchymal…

  • Stem Cell-ebration: 5 Years of Breakthrough Science and Insightful Conversations

    April 14, 2026 · 51 min

    Five years ago, The Stem Cell Report set out with a simple goal: to bring the science, the people, and the stories behind stem cell research into one conversation. Since then, the field has advanced at an extraordinary pace—transforming…

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  • Making Sense of Touch

    March 9, 2026 · 46 min

    Our guests today created new lab models to study Merkel cells using mouse whisker tissue cultures, mouse skin organoids, and human skin organoids. These models allowed them to study Merkel cells as they develop, validate the role of known…

  • Illuminating hPSC-derived Sensory Neurons

    February 10, 2026 · 35 min

    Human pluripotent stem cells (hPSCs) are transforming the study of biology and disease by enabling scientists to grow large amounts of specific cell types in the lab that were once difficult to obtain. Our guests today focus on improving…

  • Tuning the X

    January 22, 2026 · 43 min

    Epigenetic regulation of gene expression is an important mechanism in development and disease. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications for RNA and has been shown to play critical roles in processes…

  • Building a Better Barrier: Modeling the Human Gut Epithelium

    November 19, 2025 · 43 min

    The human intestinal epithelial barrier comprises diverse proliferative, secretory and absorptive cell types that facilitate nutrient digestion and absorption and protect against harmful environmental agents. The barrier and its function…

  • Crossing the Border: Modeling the Blood Brain Barrier

    October 23, 2025 · 30 min

    The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of proteins between blood circulation and brain parenchyma. Human…

  • Movin’ On Out: Mobilizing HSCs From The Bone Marrow

    September 22, 2025 · 33 min

    Hematopoietic stem cells (HSCs) normally reside in the bone marrow niche but can traffic across the bone marrow endothelium into the bloodstream to populate different niches. This process of HSC mobilization from the bone marrow to the…

  • Cancer Neuroscience, Tumor Organoids, and Understanding the Role of the Nervous System in Human Glioblastoma

    August 12, 2025 · 46 min

    The role of neuronal influences on cancer pathogenesis and progression is increasingly appreciated in the nervous system. Neurons have been shown to enhance the proliferation and migration of gliomas, a glial-derived tumor of the CNS, via…

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About the show

Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Janet Rossant, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. Rossant goes “beyond the paper,” bringing authors together to draw new insights and explore the questions and creativity that drive new breakthroughs. Stem Cell Reports, published by the International Society for Stem Cell Research (ISSCR), is an open-access, peer reviewed journal that supports the field of stem cell research and regenerative medicine.