Brainforest Café
Similar topics: ibogaine and plant
Science
Ibogaine: The Molecule, The Plant, and The Promise
by Jim Mitchell
Today: #169 in Science, South Africa on our combined chart.
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Ranking history · Philippines
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Latest episodes
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Episode 11 - From Root to Release
September 17, 2026 · 49 minEpisode 11 steps outside the sterile pharmaceutical framework to examine Tabernanthe iboga and Voacanga africana as dynamic, living biological systems within equatorial West Central African ecosystems. Rather than viewing these plants…
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Episode 10: Into the Clinic - Indications, Trials Past, Present & Future
September 17, 2026 · 46 minThe series capstone maps the full clinical landscape. The hosts review primary and secondary indications — opioid use disorder (the flagship), other substance use disorders (cocaine, alcohol, methamphetamine, nicotine), PTSD, TBI, and…
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Episode 9: Engineering Around the Problem - 18-MC, Tabernanthalog & Next-Generation Analogs
September 17, 2026 · 43 minEpisode 9 tells the medicinal-chemistry redemption arc: how chemists tried to retain ibogaines therapeutic core while deleting cardiotoxicity and the multi-hour hallucinogenic experience. 18-methoxycoronaridine (18-MC) is presented as a…
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Episode 8: The Central Danger - Cardiotoxicity, hERG & QT Prolongation
September 17, 2026 · 36 minEpisode 8 is the series safety cornerstone. Cardiotoxicity is introduced as the single biggest barrier to ibogaine becoming an approved medicine. The mechanism is explained at the channel level: hERG (Kv11.1) potassium-channel blockade…
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Episode 7: Polypharmacology - How Ibogaine Actually Works (and Noribogaine)
September 17, 2026 · 51 minThis episode delivers the definitive mechanistic tour: ibogaine is a textbook "dirty drug" acting across many targets. The hosts enumerate its bindings — NMDA antagonism, α3β4 nicotinic acetylcholine receptor antagonism (the leading…
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Episode 6 · Building the Cage - Total Synthesis Semi-Synthesis
September 17, 2026 · 58 minEpisode 6 is a synthesis seminar: it explains the iboga skeleton as a classic synthetic challenge and surveys landmark and modern approaches. Buechis 1966 total synthesis is framed as the reference point, with modern asymmetric and…
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Episode 5 · Getting the Molecule Out - Extraction, Isolation, Purification & Impurity Profiling
September 17, 2026 · 50 minThis episode bridges chemistry and quality by explaining how ibogaine is separated from plant material and purified to an API specification. Acid-base alkaloid partitioning and the distinction between crude total-alkaloid extract and…
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Episode 4 · From Field to Feedstock - Cultivation, Sourcing & Sustainability
September 17, 2026 · 40 minEpisode 4 follows raw material from field to feedstock, examining the agronomy of both source species and why cultivating iboga is genuinely difficult. The discussion covers wild collection versus cultivation in West Africa, the ethics of…
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Episode 3 · Two Roads to Ibogaine - Tabernanthe iboga vs. Voacanga africana
September 17, 2026 · 31 minThis episode reveals why the plant everyone talks about is not the one industry actually uses. The discussion contrasts T. iboga — with its low yield, slow growth, and conservation pressures — against Voacanga africana, which dominates the…
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Episode 2: The Plant & Its Chemistry — Botany & Pharmacognosy of Iboga
September 17, 2026 · 37 minThe second episode grounds the listener in botanical and chemical fundamentals. It covers Tabernanthe iboga taxonomy, morphology, and why the root bark concentrates alkaloids. The hosts map the iboga-alkaloid family — ibogaine, ibogamine…
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Episode 1 · Origins — From Bwiti Ritual to Addiction Medicine
September 17, 2026 · 40 minThis episode establishes the series through a narrative arc of discovery and suppression. Beginning with the Bwiti spiritual tradition in Gabon and the cultural significance of the iboga plant, the hosts trace Western scientific isolation…
About the show
This podcast presents a rigorous, graduate-level scientific deep dive into ibogaine — from its botanical origins through pharmacology, synthesis, clinical trials, and the next-generation analogs poised to reshape addiction medicine. Across ten episodes of approximately 45 minutes each, two expert co-hosts guide an audience of medicinal chemists, pharmacologists, and drug-development professionals through a complete narrative arc: plant → chemistry → mechanism → danger → analogs → clinic.