Endocrine Deep Dives
Today: #141 in Education, India on our combined chart.
Chart positions today · New Zealand
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Ranking history · New Zealand
Latest episodes
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Teprotumumab
October 8, 2026 · 22 minTeprotumumab is a fully human monoclonal antibody targeting the insulin-like growth factor 1 receptor, revolutionizing the medical management of active thyroid eye disease. By blocking receptor signaling on orbital fibroblasts, it reduces…
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Fragile X Premutation
October 7, 2026 · 21 minFragile X premutation carriers harbor FMR1 allele expansions containing fifty-five to two hundred CGG repeats, predisposing them to distinct clinical syndromes driven by elevated toxic messenger ribonucleic acid levels. Adult carriers face…
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Bone Turnover Markers
October 6, 2026 · 23 minPODCAST SUMMARY: Bone turnover markers provide dynamic, real-time biochemical assessment of skeletal metabolism by quantifying bone formation through serum osteocalcin and procollagen type 1 N-terminal propeptide alongside bone resorption…
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Hyperparathyroidism: Surgery vs Bisphosphonates Timing
October 5, 2026 · 23 minPrimary hyperparathyroidism management hinges on distinguishing symptomatic from asymptomatic disease and assessing surgical candidacy according to established biochemical and densitometric thresholds. Parathyroidectomy remains the only…
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Persistent Post Thyroidectomy Tingling Despite Normocalcemia
October 2, 2026 · 27 minPost thyroidectomy hypocalcemia typically presents with perioral tingling and neuromuscular irritability driven by transient or permanent hypoparathyroidism. Early clinical identification relies on eliciting Chvostek and Trousseau signs…
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Real world use of Palopegteriparatide
October 1, 2026 · 19 minA long-acting parathyroid hormone prodrug engineered for continuous parathyroid hormone receptor type 1 activation via physiologic autocleavage. Once-daily administration maintains stable serum calcium and phosphate levels while lowering…
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Everything About Palopegteriparatide
September 30, 2026 · 17 minPalopegteriparatide is a long-acting prodrug of parathyroid hormone designed for once-weekly subcutaneous administration in hypoparathyroidism. By providing sustained physiological systemic exposure, it normalizes serum calcium and urinary…
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Levothyroxine Interactions and More and More
September 29, 2026 · 23 minLevothyroxine absorption is highly vulnerable to gastrointestinal disruptions and concurrent ingestions. Common culprits include calcium carbonate, ferrous sulfate, proton pump inhibitors, and fiber supplements, which bind the hormone or…
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Hunt for the Elusive Neuropeptides
September 28, 2026 · 26 minThe intense rivalry between Roger Guillemin and Andrew Schally revolutionized neuroendocrinology through the isolation of hypothalamic releasing hormones. Following their initial collaboration at Baylor University, the two researchers…
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IPSS Case Studies
September 25, 2026 · 26 minInferior petrosal sinus sampling differentiates Cushing disease from ectopic adrenocorticotropic hormone secretion using simultaneous petrosal and peripheral venous hormone measurements. A normal pituitary magnetic resonance imaging does…
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Inferior petrosal sinus sampling
September 24, 2026 · 23 minInferior petrosal sinus sampling is the diagnostic gold standard for localizing the source of adrenocorticotropic hormone dependent Cushing syndrome when pituitary imaging is non diagnostic or discordant. The procedure relies on comparing…
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Testing for 1-25 dihydroxy Vitamin D
September 23, 2026 · 26 minAssessing nutritional vitamin D status requires measuring 25-hydroxyvitamin D, as serum 1,25-dihydroxyvitamin D is tightly regulated by parathyroid hormone, calcium, and phosphate, often remaining normal or paradoxically elevated in severe…