Clinical Pharmacology Podcast with Nathan Teuscher podcast artwork
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Clinical Pharmacology Podcast with Nathan Teuscher

by Nathan Teuscher
Life SciencesScience

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Latest episodes

  • Exposure-Response modeling

    October 2, 2026 · 30 min

    Today’s episode is about exposure response modeling. What is ER analysis? When is it used? How do you do it? And what tools can be used for ER modeling? Links discussed in the show: ICH M15 Guideline You can connect with me on LinkedIn and…

  • Renal and Hepatic Impairment (Ep. 59)

    August 24, 2026 · 29 min

    Today’s episode is a discussion of renal and hepatic impairment. I review the biology of the kidney and liver and how we analyze pharmacokinetic data to assess their impact on drug exposure. Links discussed in the show: You can connect…

  • Beyond Small Molecules—Allometric Scaling for Biologics and Engineered mAbs (Ep. 58)

    July 27, 2026 · 20 min

    Today’s episode is about allometric scaling with therapeutic antibodies. I discuss differences from small molecules, how to handle antibodies with engineered Fc regions (e.g. YTE or LS), and using allometry to extrapolate from adults to…

  • Bioequivalence Testing: The Stats Behind Generic Drug Approvals (Ep. 57)

    May 25, 2026 · 24 min

    In this episode I discuss bioequivalence testing and how it was developed to support generic drug approvals, but is now a mainstream tool for all of drug development. I discuss the basics of what bioequivalence means, how the studies are…

  • Examining Volume of Distribution (Ep. 56)

    April 20, 2026 · 19 min

    In this episode we’re going to define Volume of Distribution, look at the different types of Volume of Distribution parameters, talk about how we actually calculate it, examine what drives its value, and—most importantly—discuss why it…

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  • Talking about data science with Mike Stackhouse (Ep. 55)

    March 16, 2026 · 45 min

    This episode is an interview with Michael Stackhouse, the Chief Innovation Officer at Atorus Research. We discussed a variety of topics such as modern data science tools, why regulatory agencies want to get rid of SAS transport files in…

  • Using Accelerator Mass Spectrometry in Clinical Pharmacology

    February 16, 2026 · 38 min

    This episode is an interview with Dr. Wouter Vaes, the Chief Science Officer of Peregrion. We discuss how accelerator mass spectrometry is being used in early clinical development for drug metabolism and pharmacokinetics. We discuss using…

  • Using AI tools for regulatory intelligence (Ep. 53)

    January 19, 2026 · 21 min

    This episode is an interview with Aruna Dhontabhaktuni, Founder and CEO of RegKey, a regulatory intelligence platform that uses AI. The discussion touches on how companies can leverage large language model AI tools to accelerate regulatory…

  • When to use model-informed drug development (Ep. 52)

    December 22, 2025 · 28 min

    This episode is a collection of my thoughts on model-informed drug development and where different modeling modalities fit into the development schedule. These are just my opinions and each development program is different. Links discussed…

  • QSP Modeling with Ahmed Elmokadem (Ep. 51)

    November 24, 2025 · 45 min

    In this episode I chat with Ahmed Elmokadem about QSP modeling. Ahmed, from Metrum Research Group, is an expert consultant in QSP modeling and how it can be used to provide a framework to connect mechanistic understanding with clinical…

  • CDISC datasets and ACoP 2025 (Ep. 50)

    October 27, 2025 · 19 min

    In this episode I discuss dataset-JSON, a new proposed data standard for CDISC files and explain some of the CDISC files I use in my clinical pharmacology work. I end with some brief thoughts about the ACoP 2025 meeting in Denver in…

  • Statistics in Pharmacokinetics (Ep. 49)

    September 22, 2025 · 25 min

    In this episode I discuss review statistics that are commonly used in pharmacokinetics and pharmacometrics work. I reviewed the basic theory of the normal distribution and then discussed various individual statistics that we use in PK…

Full episode archive on Apple Podcasts →

About the show

I discuss clinical pharmacology and pharmacometrics topics from the perspective of drug development scientists. I share my expertise and knowledge about designing and conducting clinical pharmacology studies and discuss how to analyze the data using the most effective approaches. I draw from my experience of over 20 years working in drug development organizations and consultancies.