Science

Dose of Discovery

by Søren Hough

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Latest episodes

‘Nobody Called’: Katalin Karikó on the mRNA breakthrough that changed medicine

September 23, 2026 · 1 hr 13 min

Decades of curiosity and determination helped Katalin Karikó turn overlooked research into a technology that changed the course of a pandemic. The mRNA pioneer and Nobel laureate joins Søren and AJ to discuss how she navigated demotion and…
Snail Chemistry: Anne Conibear on how small changes reshape peptide and protein biology

August 26, 2026 · 55 min

What can cone snail venom teach us about peptides and new medicines? Anne Conibear joins Søren and AJ to explain how small chemical changes can affect protein and peptide behavior in the cell. A lockdown project investigating cone snail…
CRISPR’s 'Wild West': Erik Sontheimer on the evolution of genome editing

July 29, 2026 · 1 hr 3 min

CRISPR pioneer Erik Sontheimer joins hosts Søren and AJ to discuss how curiosity-driven research revealed a powerful genome editing technology. Their conversation looks at the landmark research that revealed how CRISPR could target DNA and…
Making the Medicine: Cheng Yi Chen on Scaling Drugs from Lab to Launch

June 24, 2026 · 52 min

It may seem obvious, but not all drugs are manufacturable. Getting an exciting new treatment from the lab to patients is only possible if the molecule or substance itself is scalable. In this episode of Dose of Discovery, hosts Søren and…
Genetic Mechanic: Stanley Crooke on Fixing Nano-Rare Disease with Oligos

May 27, 2026 · 59 min

In this episode of Dose of Discovery, hosts Søren and AJ speak to physician-scientist Stanley Crooke, CEO of the nonprofit n-Lorem Foundation, about how antisense oligonucleotide (ASO) technology has evolved into a revolutionary…

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Serendipity and siRNA: Julia Alterman on Expanding RNA Therapeutics

April 22, 2026 · 1 hr 2 min

Welcome to Dose of Discovery: a dose of breakthrough medical discoveries, delivered with your morning coffee. (Coffee not included.) In this first episode, hosts AJ and Søren speak to Julia Alterman, assistant professor at the RNA…
Dose of Discovery - Trailer

April 8, 2026 · 2 min

Dose of Discovery is a monthly science podcast about the people, ideas, and challenges shaping modern biomedicine. Tune in as hosts Søren and AJ have thoughtful, accessible conversations with leading scientists about complex subjects…

Full episode archive on Apple Podcasts →

About the show

Dose of Discovery is BioXconomy's monthly science podcast about the ideas, research, and people shaping modern biomedicine. Hosts AJ and Søren bring their scientific training to make sense of biomedical discovery for listeners. The show brings thoughtful, accessible conversations to subjects that often feel closed off or over-complicated. Each month, they sit down with leading scientists to explore research shaping oligo therapeutics, mRNA technology, and advanced therapies, and more, tracing how those ideas move from research toward real-world impact. For biotech professionals, researchers, and curious listeners, Dose of Discovery offers smart, grounded science conversation with a warm over-coffee feel. Be sure to check out BioXconomy for more deep-dive conversations about the latest in biomedical research. Hosted on Acast. See acast.com/privacy for more information.